QuEChERS: The Dispersive Methodology Approach for Complex Matrices


Sample preparation is one of the most difficult and time-consuming parts of any analytical procedure. It has a big impact on the results and makes up a crucial step for the analysis of complex matrices. Recent trends, to comply with green analytical chemistry, demand for sample preparation protocols that are non-time consuming, low-cost, easy, environmental friendly and efficient. The development of alternative sample preparation techniques has been exploited aiming to better results.

QuEChERS (quick, easy, cheap, effective, rugged, and safe) methodology is a dispersive approach widely used for the extraction and subsequent determination of an extensive range of analytes especially in residues’ analysis. QuEChERS was introduced in 2003 by Anastassiades M for the determination of pesticides residues from fruits and vegetables. The procedure includes two steps. The first step involves the extraction of the sample with an organic solvent such as acetonitrile followed by partitioning of a salt solution. The supernatant is subsequently purified by Dispersive Solid Phase Extraction (DSPE).

In conclusion, QuEChERS has been used successfully in many kinds of samples and demonstrated better clean up ability and higher recovery rates than many other already existing methods. Nowadays, this methodology constitutes a common sample preparation for routine analysis in residue laboratories for the determination of various compounds, such as pesticides, pharmaceutical products and veterinary drugs. In general, this sample preparation technique fulfils the requirements of the modern laboratories because it provides efficiently very clean extracts, in less steps and time.


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